In operation…

ORANGE TRIALS

An international consortium determined to improve liver surgery
RANDOMIZE!

Design

We design international multicentre (randomized controlled) trials.

Manage

We manage international multicentre (randomized controlled) trials.

Publish

We publish the outcomes of multicentre (randomized controlled) trials.

7
Countries
21
Hospitals
5
Trials
4
Publications
ORANGE II
22%
ORANGE II PLUS
100%
ORANGE III
100%
ORANGE SEGMENTS
55%
ORANGE I

Preoperative oral nutritional supplements, postoperative laxatives, preoperative oral nutritional supplements and postoperative laxatives or neither after liver surgery.

ORANGE II

Open versus laparoscopic left lateral sectionectomy.

ORANGE II PLUS

Open versus laparoscopic hemihepatectomy.

ORANGE III

Preoperative Movicolon versus no preoperative Movicolon.

ORANGE SEGMENTS

Open versus laparoscopic parenchymal preserving posterosuperior liver segment resection.

It’s always too early until, unfortunately, it’s suddenly too late

Martin Buxton ─ Health Serv Manage Res, 1988

The bird is the best!

Henri Bismuth ─ Cape Town, 2013

TRIALISTS

Mohammed Abu Hilal

Principal Investigator - University Hospital Southampton

Luca Aldrighetti

Principal Investigator - San Raffaele Hospital Milan

Somaiah Aroori

Principal Investigator - University Hospitals Plymouth

Marc Besselink

Principal Investigator - Amsterdam Medical Center Amsterdam

Rafael Díaz-Nieto

Principal Investigator - Aintree University Hospital

Ronald van Dam

Principal Investigator - Maastricht University Medical Center+

Mathieu D’Hondt

Principal Investigator - General Hospital Groeninge Kortrijk

Bjørn Edwin

Principal Investigator - Oslo University Hospital

Peter Lodge

Principal Investigator - The Leeds Teaching Hospitals

Valerio Lucidi

Principal Investigator - Erasmus Hospital Brussels

Krishna Menon

Principal Investigator - King's College Hospital London

Ulf Neumann

Principal Investigator - University Clinic Aachen

John Primrose

Principal Investigator - University Hospital Southampton

Gregory Sergeant

Principal Investigator - Jessa Hospital Hasselt

Aali Sheen

Principal Investigator - Manchester University Hospital

Zahir Soonawalla

Principal Investigator - Oxford University Hospitals

Robert Sutcliffe

Principal Investigator - University Hospitals Birmingham

Roberto Troisi

Principal Investigator - Ghent University Hospital

Steven White

Principal Investigator - The Freeman Hospital Newcastle